منابع مشابه
Homology modeling and structural analysis of human P-glycoprotein
UNLABELLED Homology modeling and structural analysis of human P-glycoprotein (hP-gp) were performed with a software package the Molecular Operating Environment (MOE). A mouse P-gp (mP-gp; PDB code: 3G5U) was selected as a template for the 3D structure modeling of hP-gp. The modeled hP-gp showed significant 3D similarities at the drug biding site (DBS) to the mP-gp structure. The contact energy ...
متن کاملEffect of Honey on CYP3A4 Enzyme and P-Glycoprotein Activity in Healthy Human Volunteers
The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...
متن کاملAnnotating Human P-Glycoprotein Bioassay Data
Huge amounts of small compound bioactivity data have been entering the public domain as a consequence of open innovation initiatives. It is now the time to carefully analyse existing bioassay data and give it a systematic structure. Our study aims to annotate prominent in vitro assays used for the determination of bioactivities of human P-glycoprotein inhibitors and substrates as they are repre...
متن کاملHomology Modelling of Human E1 Ubiquitin Activating Enzyme.
Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.
متن کاملeffect of honey on cyp3a4 enzyme and p-glycoprotein activity in healthy human volunteers
the activity of cytochrome p450 isozyme 3a4 (cyp3a4) enzyme and p-glycoprotein (p-gp) is modulated by grapefruit juice and herbal drugs. cyp3a4 is the major phase i drug metabolizing enzyme and p-gp is an atp-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. honey is commonly consumed as a dietary supplement. however, its influence on human cyp3a4...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2015
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20150125